Effects of Vitamin-B Complex Supplementation on Periodontal Wound
Journal of Periodontology 2005, Vol. 76, No. 7, Pages 1084-1091
Background: Reports have demonstrated that nutrient supplements,
in
particular vitamin-B complex (Vit-B), can positively influence
wound
healing processes. However, limited information is available
on the
effects of Vit-B on periodontal wound healing.
Methods: A total of 30 patients (13 males, 17 females) presenting
with generalized moderate to severe chronic periodontitis were
enrolled in this study. All subjects presented two teeth
in the same
sextant with probing depth (PD) 5 mm and bleeding upon probing
(BOP)
in need of access flap surgery (AFS). This study was a randomized,
double-masked, placebo-controlled clinical trial. Subjects
were
instructed to take one capsule a day of either Vit-B (50 mg
of the
following: thiamine HCl, riboflavin, niacinamide, d-calcium
pantothenate, and pyridoxine HCl; 50 µg each of d-biotin
and
cyanocobalamin; and 400 mcg of folate) or placebo for 30 days
following AFS. Clinical attachment levels (CAL) and N-benzoyl-dl-
arginine-2- naphthylamide (BANA) test scores were measured
at
Results: Both groups experienced comparable levels of PD
reduction
following AFS (test: 1.57 ± 0.34; control: 1.50 ± 0.21).
Changes in
mean CAL were more favorable in Vit-B supplemented subjects
(test:
+0.41 ± 0.12; control: 0.52 ± 0.23; P = 0.024).
Stratified data
demonstrated significantly better results for the test group
in both
shallow (test: 0.08 ± 0.03; control: 1.11 ± 0.27;
P = 0.032) and deep
sites (test: +1.69 ± 0.31; control: +0.74 ± 0.23;
P = 0.037). No
significant differences were observed between groups regarding
PI,
GI, and BOP. BANA test values were significantly reduced
in both
groups after surgical treatment and no significant differences
were
noted between groups.
Conclusion: Vitamin B-complex supplement in combination with
AFS
resulted in statistically significant superior CAL gains
when
compared to placebo. J Periodontol 2005;76:1084-1091.